2019 ncov wiki cz

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  • Jan 28, 2020

2019–20 coronavirus pandemic - Wikipedia
2019–20 coronavirus pandemic – Wikipedia

2019-nCoV, HCoV-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), formerly known as the new coronavirus 2019 (2019-nCoV), is. It is in humans and is of of (COVID-19) which has been designated as the (WHO).

SARS-CoV-2 has close to the bat, from which it was likely. Animal secondary reservoir such as being involved in the introduction to human. From the perspective, SARS-CoV-2 is as a species (SARSr-CoV).

Because of the strain was first discovered in China, it is sometimes referred to as “Wuhan virus” or “Wuhan coronavirus”, though (WHO) inhibits the use of the name based on the location. To avoid confusion with the disease, WHO sometimes refer to the virus as a “virus responsible for COVID-19” or “COVID-19 virus” in public health communication. Both the virus and the disease often “coronavirus” by the general public, but scientists and most journalists typically use a more appropriate term.

Human-to-human of SARS-CoV-2 has been confirmed for. Transmission occurs mainly through coughing and sneezing within about 6 feet (1.8 m). indirect contact with contaminated surfaces is another possible cause of the infection. Initial studies have shown that the virus can survive on plastic and steel up to three days, but did not survive in the box for more than a day or copper for more than four hours. RNA viruses have also been found in patients who are infected.

What is a virus transmitted during uncertain. On February 1, 2020, (WHO) indicates that “the transmission of cases without symptoms is likely a major driver of contagion”. Thus, the majority of infections in humans is believed to be the result of transmission from asymptomatic subjects. However, the epidemiology of the early models suggest that “the shedding of pre-typical symptoms may include documented infection.”

The first known infection of SARS-CoV-2 strain found in China. The original source of transmission of the virus to humans and when tension became the remains obscure. Research into the causes of the viral strain that has resulted in the discovery of many, mostly from the genus Rhinolophus of, and two managed to found the virus in samples taken from the show the similarity of 80% for SARS-CoV-2. A third virus nucleic acid sequence of collected in having 96% similarity to the SARS-CoV-2. WHO considers likely bat natural reservoir of SARS-CoV-2, but the difference between the bat coronavirus and SARS-CoV-2 indicates that humans are infected through an intermediate host.

A metagenomic studies previously published in 2019 revealed that, the viral strains that cause, is the most widely distributed coronavirus in the sample. On February 7, 2020, it was announced that researchers had found a sample of the virus nucleic acid sequence “99% identical” with SARS-CoV-2. When released, the results explain that “the receptor-binding domain of protein S newfound pangolin-CoV is almost identical to the 2019-nCoV, with one difference.” Pangolin is protected under Chinese law, but they are to be used in the general detritus.

Microbiologists and genetics have independently found evidence indicating the involvement of pangolins in coronavirus in SARS-CoV origin-2. However, pangolins coronavirus found until now only the 92% share of the entire genome with SARS-CoV-2, which is not enough to prove pangolin intermediate host; In comparison, the SARS virus responsible for the outbreak 2002-2004 together with 99.8% of the genome of the coronavirus known.

SARS-CoV-2 family of viruses known as comprehensive. This is the (+ ssRNA) virus. Another coronavirus are capable of causing diseases ranging from more severe illness such as (mer). This is the seventh known coronavirus to the people it infects, after ,,,,, and native SARS-CoV.

As the SARS-associated coronavirus strain involved in the outbreak of SARS in 2003, SARS-CoV-2 is a member of the subgenus (offspring B). The sequence is approximately 30,000 in length. SARS-CoV-2 is unique among betacoronaviruses known in the incorporation of the polybasic cleavage site, the characteristics of which are known to increase and other viruses.

With a sufficient number of sequencing, it is possible to reconstruct fromfamily history of the mutation of the virus. By January 12th, 2020, five of the SARS-CoV genome-2 have been isolated from Wuhan and reported by (CCDC) and other institutions; the number of genomes increases to 42 to 30 Jan 2020. A phylogenetic analysis of those samples showed they were “strongly associated with at most seven mutations relative to”, implying that the first human infection occurred in November or December 2019. On March 13, 2020, 410 SARS -CoV-2 genome samples on five continents available to the public.

On 11 February 2020, (ICTV) announced that according to the existing rules that calculate the hierarchical relationship between the coronavirus on the basis of five, the difference between what was then called the 2019-nCoV and not sufficient to make them separate. Therefore, they identify the 2019-nCoV as from.

Each of the SARS-CoV-2 is approximately 50-200 diameter. As another coronavirus, SARS-CoV-2 has four structural proteins, known as S (spike), E (envelope), M (membrane), and N () protein; protein N holds genomic RNA, and protein S, E, and F together create. Spike protein, which has been imaged at the atomic level using, is a protein that is responsible for allowing the virus to attach to host cells.

experiment on viral spike protein immediately suggested that SARS-CoV-2 has a sufficient affinity for (ACE2) receptor of human cells for use as a mechanism. By January 22, 2020, a group in China working with full viral genome and groups in the United States using methods independently and experimentally demonstrated that ACE2 can act as a receptor for SARS-CoV-2. Research has shown that the SARS-CoV-2 has a higher affinity for human ACE2 than the original strain of SARS virus. SARS-CoV-2 was also used to get into the cell.

Initial priming by the spike protein (TMPRSS2) is very important for the entry of SARS-CoV-2. After the SARS-CoV-2 virions attach to the target cells, cutting open the cell TMPRSS2 virus spike protein, showed. virion then releasing the RNA into the cell, forcing the cell to produce copies of the virus to infect more cells. [] SARS-CoV-2 produces at least three that promote shedding new virions from host cells and inhibit.

Based on the low variability exhibited between the known SARS-CoV-2 sequences, suspense alleged to have been detected by health authorities in the week they appear among the human population at the end of 2019. The case is currently known early infection suspected to have been found on 17 November 2019. The virus then spread to all provinces in China and more than a hundred other countries in Asia, Europe, North America, South America, Africa, and Oceania. Human-to-human transmission of the virus has been confirmed in all these areas. On 30 January 2020, the SARS-CoV-2 set by the WHO, and on March 11, 2020 the WHO declared it.

On March 20, 2020 (04:15 UTC), there were 244 517 cases of infection, 81 193 were in China mainland. While the proportion of infections that lead to infection is confirmed or diagnosed disease progression remains unclear, one of the mathematical models estimated number of people infected in Wuhan alone in 75 815 per January 25, 2020, at the time of confirmed infections is much lower. The total number of deaths attributed to the virus is 10 030 per March 20, 2020 (04:15 UTC); 86 025 people have been cured of the infection at the time. Under a third of all deaths occurring in, where Wuhan is located. Before February 24th 2020, the proportion is more than 95%.

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) From the virus has been estimated at between 1.4 and 3.9. This means that any infection from this virus is expected to produce 1.4 to 3.9 new infections when no members of society and nothing was taken.

Timeline of the 2019–20 coronavirus pandemic - Wikipedia
Timeline of the 2019–20 coronavirus pandemic – Wikipedia

Coronavirus disease 2019 - Wikipedia
Coronavirus disease 2019 – Wikipedia

Portal:Coronavirus disease 2019 - Wikipedia
Portal:Coronavirus disease 2019 – Wikipedia

Koronavirus – Wikipedie
Koronavirus – Wikipedie

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