coronavirus vaccine trial seattle

  • 5 min read
  • Des 04, 2019

Coronavirus vaccine trial kicks off in downtown Seattle
Coronavirus vaccine trial kicks off in downtown Seattle

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healthy volunteers will test different doses of the first vaccine to determine if it is safe.

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The first human testing of an experimental vaccine for the new coronavirus began on Monday, the National Institute of Allergy and Infectious Diseases announced.

The main purpose of this first set of tests was to determine if the vaccine is safe. If the study will determine how well it works.

trial was “” Dr. Anthony Fauci, director of the institute, said in a statement.

rapid development as potential vaccines is unprecedented, and it was probably because researchers can use what they already know about the related coronavirus that causes another disease outbreak, SARS and mer.

Despite the rapid progress, even if proven safe and effective vaccine against the virus, will not be available for at least one year.

tests were being conducted at Kaiser Permanente Washington Health Research Institute in Seattle, use.

Seattle selected as the test site before the United States had known coronavirus case, not because of the plague which broke out there. Washington State has been hit by a virus,

Moderna using genetic material – RNA – to make the vaccine, and the company has nine other people in various stages of development, including several viruses that cause respiratory diseases. But no vaccine is made with this technology has not yet reached the market.

Institute for infectious diseases has been working with the Moderna for RNA approach can produce very rapid vaccine, said Dr. Barney Graham, deputy director of the Vaccine Research Center of the institution.

He said the researchers at the center is focused on pandemic preparedness vaccine.

“The goal here is to be ready for all the family of viruses that can infect humans,” he said.

as bad as this epidemic, Dr. Graham said, in a way it was fortunate that the coronavirus caused, at least partly because researchers are ready for it. If another type of virus has caused outbreaks, it could take months longer to make a potential vaccine.

Another company, uses a different approach, also trying to produce vaccines coronavirus. Moderna is the first to reach the clinical trial.

The trial will enroll 45 healthy adults ages 18 to 55. Each will receive two shots, 28 days apart. Moderna call mRNA Vaccine 1273

Three different doses will be tested -. Each 15 – and participants will be studied to determine whether the vaccine is safe and whether it stimulates the immune system to produce antibodies that can stop the virus from replicating and prevent the disease it causes.

Participants four vaccinated on Monday, and four more to get a shot on Tuesday. Then there will be a pause to monitor them, before more participants received injections, said Dr. Graham.

The participants will be followed for a year, but St├ęphane bancel, Moderna chief executive, said in an interview that safety data will be available a few weeks after the shot is given. If the vaccine appeared safe then, he said, Moderna will ask the Food and Drug Administration for permission to move forward into the next phase of testing even before the first phase is completed.

The second round of testing, to measure success and to verify the safety, will include more participants.

Moderna, with headquarters in Cambridge, Mass., And a manufacturing plant in nearby Norwood, already bought new equipment that will be able to produce millions of doses. Pak bancel acknowledged that the company was taking a risk, because it is not safe or efficacy has been proven yet.

“People are suffering and time is of the essence,” he said. “Every day is important. We have taken this decision to take a risk, because we believe it is the right thing to do. “

The company’s stock price surged in February in response to news reports about vaccine. And on Monday, Moderna shares rose more than 24 percent, rising $ 5.19 to close at $ 26.49.

Work on the vaccine began in January, shortly after the Chinese scientists posted the genetic sequence of the new coronavirus in the internet. Researchers at Moderna and the National Institute of Allergy and Infectious Diseases identified part of a sequence that codes for a spike-like protein on the surface of the virusattaches to human cells, helps the virus to invade them.

A non-profit group, the Coalition for Innovation Epidemic Preparedness, help pay to produce a vaccine for the trial.

That sort surge is the basis for a vaccine. Moderna virus itself does not need to produce its vaccine :. Companies synthesize stretch of RNA required for vaccines and embeds in lipid nanoparticles

By February 24, Moderna has a batch of vaccine is ready to send to the infectious disease institute, to be used in the trial. On 4 March, the Food and Drug Administration gave permission for the trial to start

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Updated March 17, 2020

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