covid 19 vaccine seattle

  • 5 min read
  • Feb 10, 2020

Coronavirus vaccine trial underway in Seattle: Photos of first shots
Coronavirus vaccine trial underway in Seattle: Photos of first shots

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Monday, March 16, 2020

Study enroll healthy adult volunteers based in Seattle.

Phase 1 clinical trial evaluating the studied vaccine designed to protect against coronavirus disease in 2019 (COVID-19) has started at Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle. , Part of the National Institutes of Health, funded the trial. KPWHRI is part of NIAID. Open-label trial will enroll 45 healthy adult volunteers aged 18 to 55 for about 6 weeks. The first participants received the vaccine under study at this time.

This study evaluated different doses of an experimental vaccine’s safety and ability to induce an immune response in the participants. This is the first of several steps in the process of clinical trials to evaluate the potential benefits of the vaccine.

The vaccine is called mRNA 1273 and developed by the NIAID scientists and their collaborators at the biotechnology company Moderna, Inc., based in Cambridge, Massachusetts. Epidemic Preparedness Coalition for Innovation (CEPI) supports the creation of a vaccine candidate for clinical trials Phase 1.

“Finding a safe and effective vaccine to prevent infection with SARS-CoV-2 is an urgent public health priority,” said NIAID Director Anthony S. Fauci, MD’studi Phase 1, was launched in record speed, an essential first step to achieving that goal. ‘

SARS-CoV infection-2, the virus that causes COVID-19 , can cause mild to severe respiratory disease and the symptoms include fever, cough and shortness of breath. COVID-19 cases were first identified in December 2019 in Wuhan, Hubei Province, China. On March 15, 2020, have reported cases of COVID-19 153 517 and 5735 deaths worldwide. More than 2,800 confirmed COVID 19 cases and 58 deaths have been reported in the United States on March 15 under.

Currently, no approved vaccine exists to prevent infection with SARS-CoV-2.

researched vaccine was developed using genetic platform called mRNA (RNA). The vaccine studied directing the body’s cells to express viral proteins that are expected to get a strong immune response. 1273 mRNA vaccine has shown promise in animal models, and this is the first trial that examined in humans.

Scientists at NIAID Vaccine Research Center (VRC) and Moderna able to quickly develop mRNA 1273 because previous studies of coronavirus related causes severe acute respiratory syndrome (SARS) and respiratory syndrome Middle East (mer). Coronavirus round and has spikes protruding from their surface, giving the particles a crown-like appearance. Spike bind to human cells, allowing the virus to gain entry. And Moderna VRC scientists are already working on a vaccine targeting investigated Mers surge, which gives a head start to develop vaccine candidates to protect against COVID-19. Once the genetic information of the SARS-CoV-2 became available, scientists quickly selected sequences to express a spike protein in the virus stable mRNA existing platform.

Phase 1 trial was led by Lisa A. Jackson, MD, senior researcher at KPWHRI. Study participants will receive two doses of the vaccine via intramuscular injections in the upper arm about 28 days apart. Each participant will be assigned to receive 25 micrograms (mcg), 100 mcg or 250 mcg doses in the two vaccinations, with 15 people in each dose group. The first four participants will receive a single injection with a low dose, and four the next participant will receive 100 mcg dose. Investigators will review safety data prior to vaccination the remaining participants in the 25 and 100 mcg dose group and before participants received their second vaccination. Another safety review will be carried out before the participants enrolled in the 250 mcg group.

The participants will be asked to return to the clinic for follow-up visits between vaccination and for additional visits in the span of a year after the second shot. Your doctor will monitor participants for comMon vaccination symptoms, such as pain at the injection site or fever as well as other medical problems. A protocol team will meet regularly to review the safety data and safety monitoring committee will also periodically review the experimental data and advice NIAID. Participants will also be asked to provide blood samples at specific time points, the researchers will test in the laboratory to detect and measure the immune response to experimental vaccines.

“This work is very important for national efforts to respond to the threat of this virus emerged,” says Dr Jackson. “We are ready for this trial is important because of our experience as the NIH clinical trial center since 2007.”

Today in the Seattle area who are interested in joining the study should visit. For more information about this study, visit ClinicalTrials.gov and seek identifier

NIAID conducting and supporting research -. At NIH, throughout the United States, and worldwide – to study the causes of infectious diseases and immune-mediated, and to develop better means of preventing, diagnosing and treating this disease. News releases, fact sheets and NIAID-related materials are available in other

About the National Institutes of Health (NIH) .:
NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the US Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit.

NIH … Turning Invention To Health®

Today in the Seattle area who are interested in joining the study should visit. People who live outside this area will not be eligible to participate in this trial.

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NIH … Turning Invention To Health®

The National Institutes of Health, 9000 Rockville Pike, Bethesda , Maryland 20 892

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