vaccine for hantavirus pulmonary syndrome

  • 3 min read
  • Feb 02, 2020

Recent Approaches in Hantavirus Vaccine Development
Recent Approaches in Hantavirus Vaccine Development

hantavirus vaccine is a vaccine to protect humans against hantavirus infection causes (HFRS) or (HPS). The vaccine is considered important as acute Hantavirus infection is responsible for significant morbidity and mortality worldwide. It is estimated that about 1.5 million cases and 46,000 deaths occurred in China from 1950 to 2007. The number of cases is estimated to 32,000 in Finland from 2005 to 2010 and 90,000 in Russia from 1996 to 2006.

The first hantavirus vaccine was developed in 1990 originally for use against which caused one of the most severe forms of HFRS. It is estimated that approximately two million doses of the rodent brain or cell-culture derived vaccines given in China every year. The use of this kind of vaccine may be partly responsible for a significant reduction in the number of cases of HFRS in China to less than 20,000 in 2007.

other hantaviruses that this vaccine be used including Seoul (SEOV) virus. However, the vaccine is not considered effective against European hantaviruses including Puumala (PUUV) and Dobrava-Belgrade (DOBV) virus. Pharmaceutical trade name for the vaccine is Hantavax. In 2012 there hantavirus vaccine has been approved for use in Europe or the United States. An on human HTNV / DNA PUUV hantavirus vaccine is ongoing.

In addition to the three candidates Hantavax more vaccine has been studied in trials phase I-II clinical trials. They include recombinant vaccines and vaccines from HTNV and PUUV virus. However, their prospects are not clear

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